role of cell adhesion molecules in lymphocyte activation and homing.
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role of cell adhesion molecules in lymphocyte activation and homing.

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Published by University of Manchester in Manchester .
Written in English

Book details:

Edition Notes

Thesis (Ph.D.), - University of Manchester, School of Biological Sciences.

ContributionsUniversity of Manchester. School of Biological Sciences.
The Physical Object
Number of Pages221
ID Numbers
Open LibraryOL16573401M

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Vascular cell adhesion molecule (V-CAM) mediates adhesion of lymphocytes, monocytes, eosinophils, and basophils to the vascular endothelium. V-CAM is upregulated by a variety of cytokines. V-CAM-1 plays a role in the formation of atherosclerosis (Aplin et al., ).   Role of cell adhesion receptors in inflammation. An inflammatory response to foregin antigens of bacteria begins with the attraction of leukocytes that release biologically active mediators (A). These cytokines or bacterial products stimulate the expression of adhesion molecules such as ICAM-1, E-selectin, P-selectin, and VCAM-1 on the surface. Adhesion Molecules And Lymphocyte Homing Sharon S. Evans, Ph.D. Dept. Immunology, RPCI Scramble to identify cell adhesion molecules/ligands 14 α, 8 βchains of integrins identified →24 integrins to dissect role of adhesion molecules/chemokines in. The T cell and antigen-presenting cell communicate to initiate an immune response through formation of an immunological synapse. This specialized cell–cell junction is compartmentalized into adhesion molecule and T cell receptor enriched regions or SMACs. Distinct signals seem to be generated in the T cell receptor and adhesion molecule-dominated regions.

Although cell adhesion molecules play an important role in many processes, this book concentrates on their role within the immune system. A number of chapters discuss the migration of lymphocytes between hematopoietic organs such as the thymus, lymph nodes, Peyer's patches, and spleen. Alvin W. Martin, in Diagnostic Immunohistochemistry (Third Edition), intravascular large b-cell lymphoma The majority of cases express B-cell markers, although T cells have been reported. A variety of lymphocyte homing receptors have been discovered on the cell surface, allowing one to hypothesize about the mechanism of restriction of the lymphoma cells to the intravascular. molecules on endothelial cells and leukocytes that play a role in lymphocyte homing Describe the relationship between selectins and mucins Selectins and mucins are both adhesion molecules - selectins contain a lectin domain that binds to a carbohydrate group (the ligand) on the other cell and mucins are proteins coated with carbohydrate groups - where the carbohydrates are the ligands for . Start studying Chapter 11 T lymphocyte development and activation. Learn vocabulary, terms, and more with flashcards, games, and other study tools.

  Function of lymphocyte homing-associated adhesion molecules on human natural killer and lymphokine-activated killer cells. Uksila J(1), Salmi M, Butcher EC, Tarkkanen J, Jalkanen S. Author information: (1)Department of Medical Microbiology, Turku University, Finland. Cell adhesion molecules mediate many of the cell–cell interactions and cell–environment interactions that direct lymphocyte migration. Cell adhesion molecules involved in immune cell migration fall into two main categories: selectins and their ligands and integrins and their ligands. Cell-mediated immunity by Th1-type CD4+ T cells is the predominant host defense mechanism against mucosal candidiasis. However, studies using an estrogen-dependent murine model of vaginal candidiasis have demonstrated little to no change in resident vaginal T cells during infection and no systemic T-cell infiltration despite the presence of Candida -specific systemic Th1-type responses in. Activation of a naive T8-lymphocyte by a dendritic cell. One of the body's major defenses against viruses, intracellular bacteria, and cancers is the destruction of infected cells and tumor cells by cytotoxic T-lymphocytes or CTLs. These CTLs are effector cells derived from naive T8-lymphocytes during cell-mediated immunity.